![]() ![]() They discussed the potential of HOCl for treating eye infections. ![]() In November 2021, a group of Italian ophthalmologists participated in an online advisory board. 17 However, many individuals with blepharitis require long-term therapy as blepharitis is chronic, and relief of symptoms may be temporary. ![]() The main treatments for blepharitis are topical and/or systemic antibiotic therapies for bacterial aetiologies combined with topical steroids. 17, 18 Although bacteria may or may not initiate blepharitis, the oily and inflamed eyelid margins of patients with blepharitis are frequently colonized by bacteria. 15, 16 Blepharitis is a common chronic ocular surface disease that involves 37–47% of patients referring to ophthalmologists and optometrists, causing significant discomfort and symptoms that include redness, itching, burning, foreign body sensations and blurred vision. 14 Use of the HOCl ophthalmic spray is indicated as an adjuvant in treating blepharitis and for cleansing the periocular area in the days before or after ocular surgery. The HOCl ophthalmic spray is a medical device based on a 0.01% HOCl solution, the lowest pure HOCl concentration approved for the ocular surface. In clinical practice, thanks to this innovative technology, an electrolyzed ophthalmic spray based on pure, stable, pH-neutral HOCl (Ocudox™, marketed in Italy by Alfa Intes hereafter termed HOCl ophthalmic spray) can be used as an antiseptic with high disinfecting power. 13 Through the use of this technology, the development of highly stable (up to 2 years or more) and safe HOCl solutions was achieved and used for the development of commercial pharmaceutical formulations. 12 The stable HOCl formulation obtained with this technology showed a broad-spectrum antimicrobial activity and anti-inflammatory and immunomodulatory properties based on multiple laboratory analyses. ![]() 11 Therefore, a major advance has been the development of a patented technology (Microcyn ® technology) in which a single, free, chlorine stream is generated without a by-product of sodium hydroxide (NaOH). Notably, the presence of various organic compounds and inorganic ions result in rapid consumption of HOCl by oxidation reactions. The reaction between H 2O 2 and Cl − to generate HOCl is then catalysed by myeloperoxidase (MPO). Neutrophils convert O 2 to hydrogen peroxide (H 2O 2) using a mitochondrial membrane-bound enzyme (NADPH oxidase). Hypochlorous acid (HOCl) production during the oxidative burst process. ![]()
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